Protein inter-domain linker prediction using Random Forest and amino acid physiochemical properties
نویسندگان
چکیده
منابع مشابه
DomCut: prediction of inter-domain linker regions in amino acid sequences
DomCut is a program to predict inter-domain linker regions solely by amino acid sequence information. The prediction is made by using linker index deduced from a data set of domain/linker segments. The linker preference profile, which is the averaged linker index along a sequence, can be visualized in the graphical interface.
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MOTIVATION Protein interactions are of biological interest because they orchestrate a number of cellular processes such as metabolic pathways and immunological recognition. Domains are the building blocks of proteins; therefore, proteins are assumed to interact as a result of their interacting domains. Many domain-based models for protein interaction prediction have been developed, and prelimin...
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Protein-protein interaction has proven to be a valuable piece of biological knowledge and a starting point for understanding the internal workings of the cell. In this paper, we propose a novel method for protein-protein interaction prediction using only the primary structural information of the protein sequence. The method is developed based on inter-domain linker region knowledge and a combin...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2014
ISSN: 1471-2105
DOI: 10.1186/1471-2105-15-s16-s8